Degenerative
The word degenerative indicates to a condition that is characterized by progressive deterioration and loss of function in the organs or tissues. This is widely seen among aging person. There are several degenerative disorders. Some common symptoms uses tangling of neurofibrillary. Neurofibrillary tangles refers to the insoluble twisted fibers found inside the brain's cells. These tangles are made of primarily a protein called tau, it forms part of a structure which is called a microtubule. The microtubule helps in transportation of nutrients and other important substances from one part of the nerve cell to another part. In Alzheimer's disease, this tau protein is abnormal and the microtubule structures collapses. These tangles are formed when tau is misfolded in a very specific way. And is very evident in disorders like dementia. Disorders which are grouped under the general term “dementia” are predominantly caused by the abnormal brain changes. These changes largely include a decline in thinking skills, or the cognitive abilities, this degeneration can be severe enough to impair day to day activities and independent function.