Predisposed means an individual at risk of developing a certain problem, or it refers to the susceptibility of an individual towards psychopathology. It can be because of the following:
i. Genetics: Genetic studies have provided valuable information about inheritance of susceptibility to disease.
ii. Neurology: Neuropsychiatry focuses on psychiatric aspects of neurological disorder and the role of brain dysfunction in psychiatric disorder.
iii. Psychoneuroendocrinology: Psychoneuroendocrinology encompasses structural and functional relationship between hormonal system and central nervous system and the behaviour that is modulated and derived from both. .
iv. Temperament: An individual differences approach may be applied to phenomena of susceptibility of an individual towards development of a certain pathology and hence psychiatric disorders. Among the many determinants of individual differences considerable attention has been devoted to personality characteristics which are more or less stable characteristics such as: hardiness , repressions-sensitization, self esteem, self confidence and sense of coherence.